Ceol Laboratory at UMass Medical School

Venkatesan, A.M., Vyas, R., Dresser, K., Gujja, S., Bhatnagar, S., Chhangawala, S., Gomes, C., Xi, H.S., Lian, C.G., Houvras, Y., Edwards, Y.J.K., Deng, A., Green, M. and Ceol, C.J. (2018). Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. Journal of Clinical Investigation,128, 294-308.

Neto, A., Kasheta, M. and Ceol, C.J. (2018). Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling. Pigment Cell and Melanoma Research, 31, 115-19.

Darp, R. and Ceol, C.J. (2018). Chromatin modification: A novel insight into BRAF-independent spontaneous melanoma.
Pigment Cell and Melanoma Research, 31, 9-10.

Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M. and Ceol, C.J. (2017). Identification and characterization of Treg-like cells in zebrafish.
Journal of Experimental Medicine, 214, 3519-3530.

Neiswender, J., Kortum, R.L., Bourque, C., Kasheta, M., Zon, L.I., Morrison, D.K. and Ceol, C.J. (2017). KIT suppresses BRAFV600E-mutant melanoma by attenuating RAS/MAPK signaling. Cancer Research, 77, 5820-30.

Tang, Q., Iyer, S., Lobbardi, R., Moore, J., Chen, H., Lareau, C., Hebert, C., Shaw, M., Neftel, C., Suva, M., Ceol, C., Bernards, A., Aryee, M., Pinello, L., Drummond, I. and Langenau, D.L. (2017). Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single cell resolution using RNA sequencing.
Journal of Experimental Medicine, 214, 2875-87.

Gramann, A., Frantz, W.F. and Ceol, C.J. (2017). The birth of malignancy: embryogenesis and melanoma. In Melanoma Development: Molecular Biology, Genetics and Clinical Applications, A. Bosserhoff, ed. (Cham, Switzerland, Springer International Publishing), pp. 339-55.

Wojciechowska, S., Zeng, Z., Lister, J.A., Ceol, C.J., Patton, E.E. (2016). Melanoma regression and recurrence in zebrafish.
Methods Molecular Biology, 1451, 143-53.

Moore, F.E., Garcia, E.G., Lobbardi, R., Jain, E., Tang, Q., Moore, J.C., Cortes, M., Molodtsov, A., Kasheta, M., Luo, C.C., Garcia, A.J., Mylvaganam, R., Yoder, J.A., Blackburn, J.S., Sadreyev, R.I., Ceol, C.J., North, T.E. and Langenau, D.M. (2016). Single-cell transcriptional analysis of normal, aberrant and malignant hematopoiesis in zebrafish.
Journal of Experimental Medicine, 213, 979-92.

Wojciechowska, S., van Rooijen, E., Ceol, C., Patton, E.E. and White, R. (2016). Generation and analysis of zebrafish melanoma models.
Methods in Cell Biology, 134, 531-49.

Ceol, C.J. and Houvras, Y. (2016). Uncharted waters: zebrafish cancer models navigate a course of discovery. In Cancer and Zebrafish, D. Langenau, ed. (Switzerland, Springer International Publishing), 3-19.

Iyengar, S., Kasheta, M. and Ceol, C.J. (2015). Poised regeneration of zebrafish melanocytes involves direct differentiation and concurrent replenishment of tissue-resident progenitor cells.
Developmental Cell, 33, 631-43.

Painter, C.A. and Ceol, C.J. (2014). Zebrafish as a platform to study tumor progression.
Methods in Molecular Biology, 1176, 143-55.

Iyengar, S., Houvras, Y. and Ceol, C.J. (2012). Screening for melanoma modifiers using a zebrafish autochthonous tumor model. Journal of Visualized Experiments, 69, e50086.

Lian, C.G., Xu. Y., Ceol, C.J., Wu, F., Larson, A., Dresser, K., Xu, W., Tan, L., Zhan, Q., Lee, C., Hu, D., Lian, B.Q., Kleffel, S., Yang, Y., Khorasani, A.J., Lezcano, C., Duncan, L.M., Scolyer, R.A., Thompson, J.F., Kakavand, H., Houvras, Y., Zon, L., Mihm Jr., M.C., Kaiser, U.B., Schatton, T., Woda, B.A., Murphy, G.F. and Shi, Y.G. (2012). Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell, 150, 1135-46.

Richardson, J., Zeng, Z., Ceol, C.J., Jackson, I.J., Patton, E.E. (2011).
BRAFV600E nevi regenerate from an undifferentiated precursor population in zebrafish. Pigment Cell and Melanoma Research, 24, 378-81.

Ceol, C.J.*, Houvras, Y.*, Jane-Valbuena, J., Bilodeau, S., Orlando, D., Battisti, V., Fritsch, L., Lin, W., Hollmann, T.J., Ferré, F., Bourque, C., Burke, C., Turner, L., Uong, A., Johnson, L.A., Beroukhim, R., Mermel, C., Loda, M., Ait-Si-Ali, S., Garraway, L., Young R.A. and Zon, L.I. (2011). The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma. Nature, 471, 513-7.

North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C.J., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., Zon, L.I. (2009). Hematopoetic stem cell development is dependent on blood flow.
Cell, 137, 436-48.

Freeman, J.L., Ceol, C.J., Feng, H., Langenau, D.M., Belair, C., Stern, H.M., Song, A, Paw, B.H., Look, A.T., Zhou, Y., Zon, L.I. and Lee, C. (2009). Construction and application of a cytogenetically-validated zebrafish-specific array CGH platform.
Genes Chromosomes Cancer, 48, 155-70.

Goessling, W., North, T.E., Lord, A.M., Ceol, C.J., Weidinger, G., Lee, S., Strijbosch, R., Haramis, A., Puder, M., Clevers, H., Moon, R.T. and Zon, L.I. (2008). APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology, 320, 161-74.

Langenau, D.M., Keefe, M.D., Storer, N.Y., Jette, C.A., Smith, A.C., Ceol, C.J., Bourque, C., Look, A.T. and Zon, L.I. (2008). Coinjection strategies to modify radiation sensitivity and tumor initiation in transgenic zebrafish,
Oncogene, 27, 4242-8.

White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C.J., Bourque, C., Dovey, M., Goessling, W., Burns, C.E. and Zon. L.I. (2008). Transparent adult zebrafish as a tool for in vivo transplantation analysis.
Cell Stem Cell, 2, 183-9.

Harrison, M.M., Ceol, C.J., Lu X. and Horvitz, H.R. (2006). Some
C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. USA. 103, 16782-7.

Ceol, C.J., Stegmeier, F., Harrison, M.M. and Horvitz, H.R. (2006). Identification and classification of genes that act antagonistically to
let-60 Ras signaling in Caenorhabditis elegans vulval development. Genetics. 173, 709-26.

Ceol, C.J. and Horvitz, H.R. (2004). A new class of
C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Developmental Cell. 6, 563-76.

Thomas, J.H.*, Ceol, C.J.*, Schwartz, H.T. and Horvitz, H.R. (2003). New genes that interact with
lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Genetics. 164, 135-51.

Ceol, C.J. and Horvitz, H.R. (2001).
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Molecular Cell. 7, 461-73.
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